Structure biology of selective autophagy receptors
نویسندگان
چکیده
منابع مشابه
Structure biology of selective autophagy receptors
Autophagy is a process tightly regulated by various autophagy-related proteins. It is generally classified into non-selective and selective autophagy. Whereas non-selective autophagy is triggered when the cell is under starvation, selective autophagy is involved in eliminating dysfunctional organelles, misfolded and/or ubiquitylated proteins, and intracellular pathogens. These components are re...
متن کامل[Structural biology of autophagy].
生命は自身の構成要素,特にタンパク質の合成と分 解のバランスを保つことで恒常性を維持している.タ ンパク質の分解は 2 つの主要な分解系,すなわちユビ キチン・プロテアソーム系と液胞・リソソーム系が 担っている.分解コンパートメントである液胞・リソ ソームへ細胞内のタンパク質やオルガネラなどを輸送 し,分解するシステムはオートファジーとよばれ,い くつかの種類が存在するが,本稿ではそのうち最も主 要な過程であるマクロオートファジーのことをオート ファジーとよぶ.オートファジーによるタンパク質分 解は以下の過程で進行する 1).まず細胞質内に突如隔 離膜が出現する.隔離膜は伸張しながら細胞質の一部 をランダムに取り囲み,二重膜構造体であるオート ファゴソームを形成する.オートファゴソームは酵母 や植物では液胞,哺乳類ではリソソームと融合し,内 膜ごと内容物が各種加水分解酵素の働きで分解...
متن کاملSelective autophagy.
During the last decade it has become evident that autophagy is not simply a non-selective bulk degradation pathway for intracellular components. On the contrary, the discovery and characterization of autophagy receptors which target specific cargo for lysosomal degradation by interaction with ATG8 (autophagy-related protein 8)/LC3 (light-chain 3) has accelerated our understanding of selective a...
متن کاملSelective Types of Autophagy
1Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands 2Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan 3BioScience Center, San Diego State University, San Diego, CA 92182, USA 4Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo,...
متن کاملSelective Autophagy in Drosophila
Autophagy is an evolutionarily conserved process of cellular self-eating and is a major pathway for degradation of cytoplasmic material by the lysosomal machinery. Autophagy functions as a cellular response in nutrient starvation, but it is also associated with the removal of protein aggregates and damaged organelles and therefore plays an important role in the quality control of proteins and o...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2016
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2016.49.2.265